Information about the use of stone tools in the past is encoded in the wear patterns left on their surface; however, post-depositional processes can modify and obstruct these traces. One aim in the field of lithic functional analysis is to develop methods to detect and quantify these traces on stone tools. The occlusal fingerprint analysis (OFA) is a well-established method in dental wear studies to virtually simulate dental occlusal (contact between teeth) stroke movements and thus locate and quantify the sequential contact between opposing tooth crowns. Reaching across disciplines, we conducted controlled experiments to test the applicability of the OFA method on stone tools to address the challenge of use-wear quantification and localisation, and therefore the identification of post-depositional wear. Our findings reveal a clear overlap between zones of experimentally produced use-wear and OFA-calculated contact areas. We demonstrate OFA as a potential method to generate models of multiscale use-wear that can be used as references on experimental tools to identify post- depositional surface modifications on stone tool artefacts.